X-Message-Number: 27874
References: <>
From: Kennita Watson <>
Subject: Re: elucidating age-associated stiffness 
Date: Thu, 27 Apr 2006 08:48:51 -0700

Doug --

I thought the last article in this set looked promising
until I noticed that it was published in 2000 -- well
before any of the glucosepane articles.  If anything were
to come of the AGE inhibitors discussed, wouldn't we have
heard more about them by now?

Live long and prosper,
Kennita

> From: Doug Skrecky <>
> [Glucosepane may be the primary driving force behind hardened  
> arteries,
> [and] affords a partial explanation for why the free
> radical theory of aging has lost credibility.]
> Ann N Y Acad Sci. 2005 Jun;1043:533-44.
> Cross-linking of the extracellular matrix by the maillard reaction in
> aging and diabetes: an update on "a puzzle nearing resolution".
> ...
> J Biol Chem. 2005 Apr 1;280(13):12310-5. Epub 2005 Jan 26.
> Glucosepane is a major protein cross-link of the senescent human
> extracellular matrix. Relationship with diabetes.
> ... [Neither vitamins nor green tea help with cross-links.]
> Diabetes. 2005 Feb;54(2):517-26.
> Paradoxical effects of green tea (Camellia sinensis) and antioxidant
> vitamins in diabetic rats: improved retinopathy and renal  
> mitochondrial
> defects but deterioration of collagen matrix glycoxidation and
> cross-linking.
> ... [Even so called AGE-breakers find glucosepane too tough a nut  
> to crack.]
> ...
> [Glucosepane breakers may be in the works...]
> Mol Cell Biol Res Commun. 2000 Jun;3(6):360-6.
> Novel inhibitors of advanced glycation endproducts (part II).

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