X-Message-Number: 27932
Date: Sat, 13 May 2006 19:42:43 -0700 (PDT)
From: Doug Skrecky <>
Subject: grape seed has an effect on brain aging

[Very expensive at the quoted dosage, but quite effective. Blueberry
appears to be the better buy. It is wonderful that there are so many
"natural" alternatives for treating and even reversing brain aging, that
cost can be a significant consideration. Unfortunately pharmaceutical
companies spend their money looking at "unnatural" (but patented)
treatments, that are generally much less effective. I'm expected big
pharma to eventually catch up, but don't hold your breath.]

Brain Res Bull. 2006 Feb 15;68(6):469-73. Epub 2005 Nov 2.
Modulatory role of grape seed extract on age-related oxidative DNA damage
in central nervous system of rats.
  Aging is the accumulation of diverse deleterious changes in the cells
and tissues leading to increased risk of diseases. Oxidative stress is
considered as a major risk factor and contributes to age related increase
in DNA oxidation and DNA protein cross-links in central nervous system
during aging. In the present study, we have evaluated the salubrious role
of grape seed extract on accumulation of oxidative DNA damage products
such as 8-OHdG and DNA protein cross-links in aged rats. Male albino rats
of Wistar strain were divided into four groups: Group I, young control
rats; Group II, young rats treated with grape seed extract
(100mg/kgb.wt.) for 30 days; Group III, aged control rats; Group IV, aged
rats supplemented with grape seed extract (100mg/kgb.wt.) for 30
days. Our results, thus, revealed that grape seed extract has inhibiting
effect on the accumulation of age-related oxidative DNA damages in spinal
cord and in various brain regions such as cerebral cortex, striatum and

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