X-Message-Number: 28987 Date: Thu, 18 Jan 2007 19:05:35 -0700 From: Kitty Antonik Wakfer <> Subject: Notice of Joint Bulk Purchase of >99% Resveratrol The following is provided for those on CryoNet who are seriously interested in the health maintenance aspects of life-extension. Notice of Joint Bulk Purchase of >99% Resveratrol Participants are being sought for a joint bulk purchase of >99% pure fully synthetic trans-resveratrol from the exact same company (Orchid Chemicals and Pharmaceuticals Ltd of Chennai, India) that supplied the resveratrol used in the last two major published mouse feeding studies http://pmid.us/17086191 http://pmid.us/17112576. In these studies trans-resveratrol, at human equivalent daily dosages of 5 and 50 mg/kg respectively, was shown to have major beneficial effects as a calorie restriction mimetic, and on enhanced mitochondrial activity resulting in more energy and stamina respectively. The pure synthetic has the advantage that it is completely free from plant contaminants which may have negative effects, while being exactly the same chemical as occurs in nature in red wine (among other sources). In order to obtain a supply of trans-resveratrol for myself and other interested parties, I am seeking others to join me in a large bulk purchase so that together we may get the far lower price per gram that the supplier will give for a large order. I have already successfully received and distributed to the initial joint purchase participants 4 kg from Orchid which is in the process of producing a large new batch to be ready by mid March 2007. This notice is for the purpose of increasing the amount that will be ordered at that time, if anyone should be interested. Here are the terms of this add-on commitment for new joint bulk purchase participants. Terms and Conditions of Joint Bulk Purchase as of Jan 18, 2007 Pricing 100 grams @ $4.00 per gram, 200 grams @ $3.65 per gram, 300 grams @ $3.40 per gram, 400 grams @ $3.25 per gram, 500 grams @ $3.15 per gram. Packaging All purchases are packaged in 50 or 100 gm amounts in polypropylene (PP) zip-lock bags with all air expelled before the bag is closed. PP bags are much more moisture and air proof than are polyethylene (PE) bags (the standard that one gets at the supermarket). Each PP bag is placed in a zip-lock PE sandwich bag for added protection. Multiple bags are then placed into a bubble envelope which is then placed inside a USPS flat rate priority mail envelope for shipments of 200 grams or less and a priority box for more than that. (For those outside the US things will be done a little differently as appropriate to your import needs.) Storage, handling and Dosage If the bags are kept in a freezer (all processes are slower at a lower temperature), and inside a light proof container (dark bottle or HDPE container), then research, reading and discussions with others suggests that there will be little degradation over a period of 2 years. The mice researchers stated nothing about storage in nitrogen during the experiment and most of the storage time was in a refrigerator mixed with chow. During actual usage everyone would be wise to expel all air from the bag whenever it is reclosed after getting some out of it. When you remove some resveratrol from a larger package, only remove enough to last for, say, ten days or 2 weeks at a time and, when not in use, keep it in a small PP ziplock bag in a dark bottle in the refrigerator. Small PP zip-lock bags will be enclosed with every shipment package for the purpose of keeping this smaller in-use amount in the refrigerator. As for dosage, standard dosage increasing procedures for any new chemical suggests that it will be safest to start at 0.5 mg/kg daily and double every 2 weeks until you reach at least 5 mg/kg (which is what Dr David Sinclair takes and what I am taking), but this is really a matter of individual choice and desire for experimentation. With respect to upper limits of dosage, note that there is no evidence of toxicity for resveratrol even at a human equivalent dosage of 75 mg/kg - http://pmid.us/15329443. Shipping and payment All prices include priority mail (USPS) shipping to US addresses and a copy of the Certificate of Analysis (COA) of the product. Insurance of package costs extra. Out of US shipping incurs a $25 surcharge (only $15 to Canada) with no customs entry guarantees. Email me your full legal name, physical and postal addresses, phone number and amount desired. Be prepared to pay in advance by check or money order in early March when the next order with Orchid will need to be placed and prepaid, since this is a joint bulk purchase and must be prepaid. I will email you when I need prepayment in March. Responsibility for Loss Everyone should be aware that although all joint purchasers received their allotted share of the first partial shipment, there is always some possibility that an entire future shipment, or merely a shipment to a particular joint purchaser, will be lost. Although as the coordinator of this prepaid joint bulk purchase I promise to do everything that I possibly can to prevent any such loss, I do not bear any responsibility for refunding any money in the case of any such loss. --Paul Wakfer - MoreLife for the rational - http://morelife.org Reality based tools for more life in quantity and quality The Self-Sovereign Individual Project - http://selfsip.org Rational freedom by self-sovereignty & social contracting -- **Kitty Antonik Wakfer MoreLife for the rational - http://morelife.org Reality based tools for more life in quantity and quality Self-Sovereign Individual Project - http://selfsip.org Rational freedom by self-sovereignty & social contracting Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=28987