X-Message-Number: 29352
From: "Yuriy Pichugin" <>
Subject: Re: #29349
Date: Sat, 24 Mar 2007 14:55:17 +0000

>Message #29349
>From: "Brian Wowk" <_
>Subject:  Ice blockers and the blood brain barrier
>Date: Fri, 23 Mar 2007 19:38:01  -0700
>

The 21 CM company (especially Dr. Wowk) performed very good work to create 
ice blockers for cryopreservation of organs for transplantation. It is very 
important for the organ cryopreservation to obtain the full recovery of the 
organs after their cryopreservation for successful transplantation. The ice 
blockers can decrease effective concentration of a vitrification mixture by 
3-5%.

My experiments with the 21CM blockers showed that the blockers can decrease 
effective concentration of CI-VM-1 by around 3%, and therethrough they can 
increase survival of rat hippocampal slices by around 3% only. It is very 
important just for the organ cryopreservation, but it is not so important 
for cryonics.

There are many more harmful factors for cryonics patients than insignificant 
increasing toxicity due to a 3% increase in concentration of vitrification 
mixtures. I do not even take into account the permeation of the blockers 
through the blood brain barrier and cell membranes. To get the same effect, 
we can use 3% of CI-VM-1 instead of 3% of the ice blockers. It is much 
cheaper for CI to use additional 3% of cheap CI-VM-1 instead of 3% of the 
expansive ice blockers.

It is should be noted that today cryonics in contrast to modern cryobiology 
should not wait for a completely perfect cryopreservation method because 
legal dead patients already have defects of human nature that resulted in 
their deanimation and all after-effects should be cured of future medical 
technologies. Cryonics is very different from today cryobiology and medicine 
because it relies on just a future perfect technology but not on today 
imperfect cryobiology and medicine that can use only natural, spontaneous 
resources of biological systems to recover them from various injuries.

Dr. Pichugin
Director of Research
Cryonics Institute

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