X-Message-Number: 29540
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From: David Stodolsky <>
Subject: Dietary Effect on Selenoprotein Activity and Gene Expression
Date: Tue, 5 Jun 2007 12:01:35 +0200

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PhD Defendant:
Cand. Polyt. Gitte Ravn-Haren

Time and Place:
Tuesday 5 June 2007 at 2:00 p.m. in Lecture Hall 1.01,
B lowsvej 17, 1870 Frederiksberg C

Subject Area:
Oxidative Defence and Cancer


Title of PhD Thesis:
Dietary Effect on Selenoprotein Activity and Gene Expression.


Title of Lecture:
Dietary Effect on Selenoprotein Activity and Gene Expression.


Summary:
Oxidative stress is a risk factor for cancer, and dietary compounds  
that enhance the enzymatic defence systems may decrease cancer risk.  
One such dietary compound is selenium which is essential for the  
catalytic activity of the glutathione peroxidases (GPXs).  
Associations between dietary and lifestyle factors and the enzymatic  
defence systems in relation to breast cancer risk were investigated.  
A SNP in GPX1 was associated with lower GPX activity and increased  
risk of breast cancer. The correlations between lifestyle factors and  
GPX activity were modified by genotype.


Principal Supervisor:
Associate Professor Susanne B gel, Department of Human Nutrition,  
Faculty of Life Sciences, University of Copenhagen.


Project supervisor:
Professor Lars Ove Dragsted, Department of Human Nutrition, Faculty  
of Life Sciences, University of Copenhagen.


Examination Committee:
Professor Per Torp Sangild, Department of Human Nutrition, Faculty of  
Life Sciences, University of Copenhagen.

Associate Professor Ole Vang, Department of Biology and Chemistry,  
Roskilde University.

D. Phil Margareth Rayman, University of Surrey, Guildford, UK


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