X-Message-Number: 29872
Date: Mon, 1 Oct 2007 09:32:38 -0700 (PDT)
From: 
Subject: membrane permeability to organic compounds

J Drug Target. 1996;4(2):103-7.
QSAR analysis of membrane permeability to organic compounds.
    Ren S, Das A, Lien EJ. University of Southern California, School of
Pharmacy, Department of Pharmaceutical Sciences, Los Angeles 90033, USA.
    A general mathematical model involving partition coefficient,
molecular weight and hydrogen bonding is used to correlate the structures
and permeability of various organic compounds through the toad urinary
bladder and human red blood cell (RBC) membranes. Log Per
(permeability) is correlated with log Po/w (partition coefficient in olive
oil/water, or ether/water), log MW (molecular weight) and Hb (hydrogen
bonds). Log Po/w is the most important factor among three parameters
examined. While increased MW always has a negative effect on the
permeability, increased Hb can have either a slightly positive or a
slightly negative effect depending on the solvent and membrane systems
used. Systematic comparison of the QSAR's (quantitative structure
activity relationship) of different biological membranes may serve as a
useful guide in drug targeting to different tissues and cell types.
PMID: 8894970

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