X-Message-Number: 30264
Date: Sun, 6 Jan 2008 15:00:34 -0800 (PST)
From:
Subject: 240, 241, & 242'nd updates on fly longevity experiments
This is the 240'th update of my fly longevity experiments. Average
temperature was 24.0 C during this run. Estimated maximal longevity using
the formula (363 - T*11.2) is 94 days.
This examines immune boosting supplements such as fucoidan, and
thymulus. Destromethorphan was tested in run #2, but it has such
interesting properties that here different doses are tested. Vasotame
contains a casein peptide extract, plus alginic acid.
Survival was quite poor in all bottles, and pathogens are suspected.
Low dose fucoidan appeared to offer a minor benefit.
Run #240 Percent Survival on Day
supplement 9 16 22 31 37 43 51 61 69
**************************************************
control one 93 85 74 52 30 19 7 0 -
control two 85 74 74 59 30 4 0 - -
dextromethorphan 1.5 mg 97 83 70 50 3 13 3 0 -
" 6 mg 100 91 70 48 30 17 4 0 -
fucoidan 52 mg 96 79 75 58 54 29 13 4 0
" 210 mg 97 77 70 47 27 3 3 3 0
thymulus 94 mg 91 76 76 62 29 14 5 0 -
" 375 mg 100 96 92 84 60 12 0 - -
vasotame 219 mg 85 65 50 27 19 4 4 4 0
" 875 mg 91 77 68 59 18 14 5 0 -
___________________________________________________
This is the 241'st update of my fly longevity experiments. Average
temperature was 24.6 C during this run. Estimated maximal longevity using
the formula (363 - T*11.2) is 88 days.
Large doses of vitamin K1 has *sometimes* improved survival in past
runs. Here I test vitamin K2 or menaquinone. I also test if NAD or SAMe
could reduce nicotiamide toxicity. Note that the NAD was unstabilized.
Survival was very poor in all bottles, probably due to using an older
breeding bottle. The highest dose of vitamin K2 did improve survival
modestly. No evidence of toxicity for high dose nicotiamide could be seen
in this test. However adding NAD did seem to increase survival slightly.
Run #241 Percent Survival on Day
supplement 10 18 24 35 43 54 60 67
********************************************
control one 86 29 11 11 4 0 - -
control two 59 38 22 13 6 0 - -
menaquinone 120 mg 69 25 6 3 0 - - -
" 480 mg 76 33 12 3 3 0 - -
" 1920 mg 66 31 20 9 9 6 3 0
nicotinamide 125 mg 64 33 12 3 3 0 - -
+ NAD 2.5 mg 70 33 21 15 3 3 0 -
+ SAMe 50 mg 55 37 5 0 - - - -
_____________________________________________
This is the 242'nd update of my fly longevity experiments. Average
temperature was 24.1 C during this run. Estimated maximal longevity using
the formula (363 - T*11.2) is 93 days.
In this run, I retest heated fly food, and ribose, as both of these
interventions appear likely to increase the glycotoxin content of fly
food. Also tested is Taraxatone, which contains a herb mixture,
including some taraxacum officinale leaf extract.
Heated fly food once again exerted no detrimental effect on survival,
while ribose actually slightly increased it. From these results it
appears unlikely that glycotoxins are a negative factor in fly survival.
Low dose Taraxatone appeared to be beneficial.
Run #242 Percent Survival on Day
supplement 12 21 29 37 47 57 72 80 90
***************************************************
control one 69 41 28 22 9 6 0 - -
control two 74 37 14 7 2 0 - - -
coffeeberry 400 mg 81 31 15 15 7 7 0 - -
" 1600 mg 54 21 8 0 - - - - -
heated (150 C - 30 min) 82 48 26 19 11 7 4 0 -
old breed control 50 50 30 10 10 5 0 - -
ribose 1/4 tsp 79 38 21 21 4 4 4 0 -
" 1 tsp 86 52 24 19 5 5 5 5 0
squalene 1/4 tsp 68 50 27 14 9 9 5 0 -
" 1 tsp 73 40 20 0 - - - - -
taraxatone 1 cap 78 56 33 29 17 11 11 11 0
" 4 caps 71 53 12 6 6 6 0 - -
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