X-Message-Number: 30565
From: "Eisab" <>
Subject: Brain barrier break
Date: Fri, 29 Feb 2008 15:18:53 -0500

>The technique uses small differences in pressure to make infused molecules 
>flow through solid tissue. This enables large >molecular weight molecules, 
>such as those used in drugs, to penetrate the brainstem. Researchers have 
>refined and >expanded the uses of CED during the past 8 years, but until 
>now, there has beenno way to track


Lonser RR, Walbridge S, Garmestani K, Butman JA, Walters H, Vortmeyer AO, 
Morrison PF, Brechbiel MW, Oldfield EH. "Successful and safe perfusion of 
the primate brainstem with a macromolecule: in vivo magnetic resonance 
imaging of macromolecular distribution during infusion." Journal of 
Neurosurgery, Vol. 97, No. 4, October 2002, pp. 905-913.



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