X-Message-Number: 3064
Date: 05 Sep 94 13:19:04 EDT
From: yvan Bozzonetti <>
Subject: CRYONICS.SCI Going into cells

	To get access at the inner part of cells is a major problem for 
many steps of the cryonics technology. The August 13 issue of New Scientist 
(# 1938) describes on page 16 an experiment where small particles (100nm in 
diameter) of magnetic materials was covered with dextran, a sugar enabling 
them to be taken up by cells.
	A chemical penetrator allowed to bypass the blood-brain boundary 
and a magnetic resonance detector was able to locate the particles inside 
neurons at the end of the experiment. The original work was published in 
Neurosurgery April 1994 issue, p. 777.

	The potential applications for cryonics could be at the following 
levels:
	- High cryoprotectant concentration is hard to pump because of the 
viscosity and can be toxic. If small droplets could be covered with a low 
viscosity product taken up by cells, there would be both, less mechanical 
problems and a lower concentration requirement to get the right amount 
inside cells.
	- Glucose  and some proteins are good conservators, if a droplet 
form with low viscosity coating could be exploited, there would be a new 
realm for cryonics.
	- Energy under the form of ATP, Ca++ channel blockers, 
anti-oxydants, chaperones molecular complexes and so one could all exploit 
the same technology.
	Making small droplets can be done very readily by sonication with 
ultrasounds, the technology is simple, cheap and efficient. It would be 
very useful if some researchers could look at these potentialities and some 
others.
	I would be happy to learn about a low viscosity sugar or sugar 
containing molecule. A neutral, low viscosity molecule mixing with sugar 
could do the job, at least this possibility would be teste. Are there any 
suggestion in this way?

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