X-Message-Number: 32584
Date: Tue, 11 May 2010 19:26:21 -0700 (PDT)
From: 
Subject: cuminaldehyde

[The main active ingredient in cumin is believed to be...]

J Agric Food Chem. 2005 Apr 6;53(7):2446-50.

Cuminaldehyde: Aldose Reductase and alpha-Glucosidase Inhibitor Derived from 
Cuminum cyminum L. Seeds.

Lee HS. Faculty of Biotechnology and Research Center for Industrial Development 
of Biofood Materials, College of Agriculture & Life Science, Chonbuk National 
University, Chonju 561-756, Korea.
Abstract

    The inhibitory activity of Cuminum cyminum seed-isolated component was 
    evaluated against lens aldose reductase and alpha-glucosidase isolated from 
    Sprague-Dawley male rats and compared to that of 11 commercially available 
    components derived from C. cyminum seed oil, as well as quercitrin as an 
    aldose reductase inhibitor and acarbose as an alpha-glucosidase inhibitor. 
    The biologically active constituent of C. cyminum seed oil was characterized
    as cuminaldehyde by various spectral analyses. The IC(50) value of 
    cuminaldehyde is 0.00085 mg/mL against aldose reductase and 0.5 mg/mL 
    against alpha-glucosidase, respectively. Cuminaldehyde was about 1.8 and 1.6
    times less in inhibitory activity than acarbose and quercitin, 
    respectively. Nonetheless, cuminaldehyde may be useful as a lead compound 
    and a new agent for antidiabetic therapeutics.
PMID: 15796577

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