anti-aging effects of raspberry ketone

X-Message-Number: 33313
Date: Fri, 4 Feb 2011 13:47:34 -0800 (PST)
From: 
Subject: anti-aging effects of raspberry ketone


Raspberry ketone grows hair, rejuvenates skin elasticity, and even reduces body 
fat.
A rodent longevity trial might show some interesting effects.

Growth Horm IGF Res. 2008 Aug;18(4):335-44. Epub 2008 Mar 5.

Effect of topical application of raspberry ketone on dermal production of 
insulin-like growth factor-I in mice and on hair growth and skin elasticity in 
humans.

Harada N, Okajima K, Narimatsu N, Kurihara H, Nakagata N. Department of 
Translational Medical Science Research, Nagoya City University Graduate School 
of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
Abstract

  Sensory neurons release calcitonin gene-related peptide (CGRP) on activation. 
  We recently reported that topical application of capsaicin increases facial 
  skin elasticity and promotes hair growth by increasing dermal insulin-like 
  growth factor-I (IGF-I) production through activation of sensory neurons in 
  mice and humans. Raspberry ketone (RK), a major aromatic compound contained in
  red raspberries (Rubus idaeus), has a structure similar to that of capsaicin.
  Thus, it is possible that RK activates sensory neurons, thereby increasing 
  skin elasticity and promoting hair growth by increasing dermal IGF-I 
  production. In the present study, we examined this possibility in mice and 
  humans. RK, at concentrations higher than 1 microM, significantly increased 
  CGRP release from dorsal root ganglion neurons (DRG) isolated from wild-type 
  (WT) mice and this increase was completely reversed by capsazepine, an 
  inhibitor of vanilloid receptor-1 activation. Topical application of 0.01% RK 
  increased dermal IGF-I levels at 30 min after application in WT mice, but not 
  in CGRP-knockout mice. Topical application of 0.01% RK increased 
  immunohistochemical expression of IGF-I at dermal papillae in hair follicles 
  and promoted hair re-growth in WT mice at 4 weeks after the application. When 
  applied topically to the scalp and facial skin, 0.01% RK promoted hair growth 
  in 50.0% of humans with alopecia (n=10) at 5 months after application and 
  increased cheek skin elasticity at 2 weeks after application in 5 females 
  (p<0.04). These observations strongly suggest that RK might increase dermal 
  IGF-I production through sensory neuron activation, thereby promoting hair 
  growth and increasing skin elasticity.
PMID: 18321745

Planta Med. 2010 Oct;76(15):1654-8. Epub 2010 Apr 27.

Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 
adipocytes.

Park KS. Nutrition & Functional Food Research Team, Korea Food & Drug 
Administration, Seoul, Korea.
Abstract

  Raspberry ketone (RK) is a natural phenolic compound of the red raspberry. The
  dietary administration of RK to male mice has been reported to prevent 
  high-fat diet-induced elevation in body weight and to increase lipolysis in 
  white adipocytes. To elucidate a possible mechanism for the antiobesity action
  of RK, its effects on the expression and the secretion of adiponectin, 
  lipolysis, and fatty acid oxidation in 3T3-L1 were investigated. Treatment 
  with 10"AuM of RK increased lipolysis significantly in differentiated 3T3-L1 
  cells. An immunoassay showed that RK increased both the expression and the 
  secretion of adiponectin, an adipocytokine mainly expressed and secreted by 
  adipose tissue. In addition, treatment with 10"AuM of RK increased the fatty 
  acid oxidation and suppressed lipid accumulation in 3T3-L1 adipocytes. These 
  findings suggest that RK holds great promise as an herbal medicine since its 
  biological activities alter the lipid metabolism in 3T3-L1 adipocytes.
AC Georg Thieme Verlag KG Stuttgart * New York.
PMID: 20425690

Life Sci. 2005 May 27;77(2):194-204. Epub 2005 Feb 25.
Anti-obese action of raspberry ketone.

Morimoto C, Satoh Y, Hara M, Inoue S, Tsujita T, Okuda H. Department of Medical 
Biochemistry, Ehime University School of Medicine, Shigenobu-cho, Onsen-gun, 
Ehime 791-0295, Japan.
Abstract

  Raspberry ketone (4-(4-hydroxyphenyl) butan-2-one; RK) is a major aromatic 
  compound of red raspberry (Rubus idaeus). The structure of RK is similar to 
  the structures of capsaicin and synephrine, compounds known to exert 
  anti-obese actions and alter the lipid metabolism. The present study was 
  performed to clarify whether RK helps prevent obesity and activate lipid 
  metabolism in rodents. To test the effect on obesity, our group designed the 
  following in vivo experiments: 1) mice were fed a high-fat diet including 0.5,
  1, or 2% of RK for 10 weeks; 2) mice were given a high-fat diet for 6 weeks 
  and subsequently fed the same high-fat diet containing 1% RK for the next 5 
  weeks. RK prevented the high-fat-diet-induced elevations in body weight and 
  the weights of the liver and visceral adipose tissues (epididymal, 
  retroperitoneal, and mesenteric). RK also decreased these weights and hepatic 
  triacylglycerol content after they had been increased by a high-fat diet. RK 
  significantly increased norepinephrine-induced lipolysis associated with the 
  translocation of hormone-sensitive lipase from the cytosol to lipid droplets 
  in rat epididymal fat cells. In conclusion, RK prevents and improves obesity 
  and fatty liver. These effects appear to stem from the action of RK in 
  altering the lipid metabolism, or more specifically, in increasing 
  norepinephrine-induced lipolysis in white adipocytes.
PMID: 15862604

Xenobiotica. 1982 Apr;12(4):249-57.

The metabolism of 4-(4-hydroxyphenyl)butan-2-one (raspberry ketone) in rats, 
guinea-pigs and rabbits.
SporstA,l S, Scheline RR.
Abstract

  1. The metabolism of 4-(4-hydroxyphenyl)butan-2-one(raspberry ketone) was 
  studied in rats, guinea-pigs and rabbits. 2. Following intragastric dosage (1 
  mmol/kg) urinary metabolite excretion was nearly complete within 24 h, 
  amounting to roughly 90% of the dose in all species. 3. The most prominent 
  urinary metabolites were raspberry ketone and its corresponding carbinol, both
  largely conjugated with glucuronic acid and/or sulphate. The extent of ketone
  reduction was greatest in rabbits. 4. Oxidative metabolism included ring 
  hydroxylation and side-chain oxidation. The latter pathway led to 1,2- and 
  2,3-diol derivatives. It is proposed that the latter undergo cleavage to 
  furnish the C6-C3 and C6-C2 derivatives detected.
PMID: 7113261

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