X-Message-Number: 33323
Date: Thu, 10 Feb 2011 20:03:48 -0800 (PST)
From: 
Subject: B cell rejuvenation

If this works in humans, then SENS just became a little easier to achieve.

Blood. 2011 Jan 12. [Epub ahead of print]

B cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B 
lineage in aging.

Keren Z, Naor S, Nussbaum S, Golan K, Itkin T, Sasaki Y, Schmidt-Supprian M, 
Lapidot T, Melamed D. Department of Immunology, Faculty of Medicine, Technion - 
Israel Institute of Technology, Haifa, Israel;
Abstract

  Aging is associated with a decline in B-lymphopoiesis in the bone marrow and 
  accumulation of long-lived B-cells in the periphery. These changes decrease 
  the body's ability to mount protective antibody responses. We show here that 
  age-related changes in the B lineage are mediated by the accumulating 
  long-lived B cells. Thus, depletion of B-cells in old mice was followed by 
  expansion of multipotent primitive progenitors (MPPs) and common lymphoid 
  progenitors (CLPs), a revival of B-lymphopoiesis in the bone marrow, and 
  generation of a rejuvenated peripheral compartment that enhanced the animal's 
  immune responsiveness to antigenic stimulation. Collectively, our results 
  suggest that immunosenescence in the B-lineage is not irreversible, and that 
  depletion of the long-lived B cells in old mice rejuvenates the B-lineage and 
  enhances immune competence.
PMID: 21228330

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