X-Message-Number: 33466 Date: Fri, 11 Mar 2011 18:36:39 -0800 (PST) From: Subject: the most damaging carcinogen is... Deuterium? The field of gerontology is dominated by biochemists. It would be ironic if the main "cause" of aging or even just cancer were to be found not in the field of biochemistry, but instead in the discipline of physics. Experiments with deuterium depleted water (DDW) in both humans and experimental animals have found that deuterium is highly carcinogenic, depresses immunity, and increases short term mortality. There is a real question whether cancer would occur in humans at all, if deuterium were not present in tap water. Could the fountain of youth be deuterium depleted water? Reality check: Much of the research on DDW can be traced back to HYD in Budapest, Hungary. There have been no long term trials with DDW. A single longevity study in drosophila flies compared distilled water with 50% deuterated water. Cancer plays no part in the mortality of these very short lived flies, which instead typically die of a motor neuron disease of unknown etiology. There has been no long term test comparing DDW (25 ppm deuterium) with 150 ppm distilled water. However checkout>> http://www.preventa.org/ Orv Hetil. 2010 Sep 5;151(36):1455-60. [Biological significance of naturally occurring deuterium: the antitumor effect of deuterium depletion]. [Article in Hungarian] Somlyai G, Molnar M, Laskay G, Szabo M, Berkenyi T, Guller I, Kovacs A. HYD Rakkutato es Gyogyszerfejleszto Kft. Budapest Pf. 695 1539. Abstract The concentration of deuterium is about 150 ppm (over 16 mmol/L) in surface water and more than 10 mmol/L in living organisms. Experiments with deuterium depleted water (30+/-5 ppm) revealed that due to D-depletion various tumorous cell lines (PC-3, human prostate, MDA, human breast, HT-29, human colon, M14, human melanoma) required longer time to multiply in vitro. DDW caused tumor regression in xenotransplanted mice (MDA and MCF-7, human breast, PC-3) and induced apoptosis in vitro and in vivo. Deuterium depleted water (25+/-5 ppm) induced complete or partial tumor regression in dogs and cats with spontaneous malignancies, it was registered as anticancer for veterinary use in 1999 (Vetera-DDW-25 A.U.V., 13/99 FVM). The hypodermic preparation of the registered veterinary drug was successfully tested in clinical investigations. Under the permission of the Hungarian Institute of Pharmacology (No. 5621/40/95) a randomized, double blind controlled, human Phase II clinical trial with prostate cancer was performed, in compliance with GCP principles, which exhibited a significant difference between the control and treated groups with respect to the examined parameters, median survival time and the extension of life-span. We suggest that cells are able to regulate the D/H ratio and the changes in the D/H ratio can trigger certain molecular mechanisms having a key role in cell cycle regulation. We suppose that not the shift in the intracellular pH, but the concomitant increase in the D/H ratio is the real trigger for the cells to enter into S phase. The decrease of D concentration can intervene in the signal transduction pathways thus leading to tumor regression. Deuterium depletion may open new perspectives in cancer treatment and prevention helping to increase the effectiveness of current oncotherapies. PMID: 20739263 Free text> (but good luck reading it!) http://www.akademiai.com/content/xg51631752r0r37g/fulltext.pdf Integr Cancer Ther. 2008 Sep;7(3):172-81. A retrospective evaluation of the effects of deuterium depleted water consumption on 4 patients with brain metastases from lung cancer. Krempels K, Somlyai I, Somlyai G. HYD LLC for Cancer Research and Drug Development, Budapest, Hungary. Abstract HYPOTHESES: Because of the number of sufferers and high mortality rate, the standard care and new therapeutic options in the treatment of brain metastasis from lung cancer are the subject of intense research. A new concept based on the different chemical and physical behavior of protium and deuterium affecting cell signaling and tumor growth has been introduced in the treatment of cancer patients. The aim of this study was to investigate the impact of deuterium depleted water (DDW) consumption in addition to conventional forms of therapy on the survival of lung cancer patients with brain metastasis. STUDY DESIGN: A series of 4 case histories was retrospectively evaluated. The patients were diagnosed with brain metastasis deriving from a primary lung tumor and started consuming DDW at the time of or after the diagnosis of the brain metastasis, which was inoperable or the surgical intervention did not result in complete regression. The primary objective was survival. METHODS: The daily water intake of the patients was replaced with DDW, which complemented the conventional forms of treatment. Patients were consuming DDW for at least 3 months. The treatment was continued with DDW of 10 to 15 to 20 ppm lower deuterium (D) content every 1 to 2 months and thus a gradual decrease was maintained in the D-concentration in the patient's body. RESULTS: DDW consumption integrated into conventional treatments resulted in a survival time of 26.6, 54.6, 21.9, and 33.4 months in the 4 patients, respectively. The brain metastasis of 2 patients showed complete response (CR), whereas partial response (PR) was detected in 1 patient, and the tumor growth was halted (no change or NC) in 1 case. The primary tumor of 2 patients indicated CR, and the lung tumor in 2 patients showed PR. CONCLUSIONS: DDW was administered as an oral anticancer agent in addition to conventional therapy, and noticeably prolonged the survival time of all 4 lung cancer patients with brain metastasis. We suggest that DDW treatment, when integrated into other forms of cancer treatment, might provide a new therapeutic option. PMID: 18815148 Rom J Physiol. 1999 Jul-Dec;36(3-4):205-18. Research concerning the radioprotective and immunostimulating effects of deuterium-depleted water. Bild W, Stefanescu I, Haulica I, Lupusoru C, Titescu G, Iliescu R, Nastasa V. University of Medicine and Pharmacy Iasi, Department of Physiology. Abstract Mice fed for 15 days with Deuterium-Depleted Water (30 ppm deuterium) had a statistically significant increased survival rate compared with control groups fed with normal distilled water (150 ppm deuterium), after 8.5 Gy irradiation (61% survival in the test group versus 25% in the control group). The hematological picture showed that normal WBC, RBC and platelet counts were maintained in the test groups. Immunological parameters (serum opsonic and bactericidal capacity, bactericidal capacity of the peritoneal macrophages) showed a marked increase in the test groups compared to a severe decrease in the control groups. Auxiliary tests using chemical radiomimetics (hydrochloric embihine) and immunosuppressors (cyclophosphamide) showed a strong protective effect of deuterium-depleted water against the decrease of the leukocyte counts and other immunologic parameters. In conditions of experimental inflammation induced with subcutaneous-implanted pellets, deuterium-depleted water feeding resulted in a statistically significant increase of the inflammatory response, demonstrated by increased percentages of PMN and lymphocytes in the peripheral blood and the increased phagocytic capacity of the peripheral blood PMN. Experimental infections induced with K. pneumoniae 506 and S. pneumoniae 558 in mice irradiated or treated with cyclophosphamide showed increased, non-specific immunity parameters. All results show a marked intensification of the immune defenses and increased proliferation of the peripheral blood cells, probably accounting for the radioprotective effects. PMID: 11797936 59% complete tumor regression on DDW!! FEBS Lett. 1993 Feb 8;317(1-2):1-4. Naturally occurring deuterium is essential for the normal growth rate of cells. Somlyai G, Jancso G, Jakli G, Vass K, Barna B, Lakics V, Gaal T. HYD Ltd. for Research and Development, Budapest, Hungary. Abstract The role of naturally occurring D in living organisms has been examined by using deuterium-depleted water (30-40 ppm D) instead of water containing the natural abundance of D (150 ppm). The deuterium-depleted water significantly decreased the growth rate of the L929 fibroblast cell line, and also inhibited the tumor growth in xenotransplanted mice. Eighty days after transplantation in 10 (59%) out of 17 tumorous mice the tumor, after having grown, regressed and then disappeared. We suggest that the naturally occurring D has a central role in signal transduction involved in cell cycle regulation. PMID: 8428617 50% deuterium countered the extremely powerful anti-aging effect of temperature reduction in flies. Body temperature reduction in cold blooded animals is, by a large margin, the most powerful means to increase life span. No one really knows why aging is so temperature dependant, and no one knows why deuterium counters this effect. Although a 20 C temperature decrease increased longevity here over four fold may seem an outlandish result, it is actually a typical finding, which is representative of other experiments in cold blooded animals. Temp Distilled 50% C water deuterium 30 25 19 25 51 36 20 89 29 10 112 7 Science. 1974 Feb 1;183(123):427-8. Deuterium oxide effect on temperature-dependent survival in populations of Drosophila melanogaster. Samis HV, Baird MB, Massie HR. Abstract A comparison of the mean life-spans for populations of Drosophila melanogaster at 10 degrees , 20 degrees , 25 degrees , and 30 degrees C maintained on media prepared with distilled water and with 50 percent deuterium oxide shows that deuteration decreases longevity at all four temperatures. The magnitude of the difference between the mean survival times of populations maintained on deuterated and nondeuterated media is inversely related to temperature between 10 degrees and 30 degrees C. PMID: 4203023 Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=33466