X-Message-Number: 3623 From: (Thomas Donaldson) Subject: CRYONICS:re.brain.neurotransmitters Date: Fri, 6 Jan 1995 20:58:21 -0800 (PST) AN 94365665 AU Dawson TM. Snyder SH. IN Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205. TI Gases as biological messengers: nitric oxide and carbon monoxide in the brain. [Review] SO Journal of Neuroscience. 14(9):5147-59, 1994 Sep. JC jdf CP United States AB In a remarkably brief period of time, NO and CO have been recognized as putative neurotransmitters. These two novel messenger molecules have greatly expanded the criteria for candidacy of a chemical for the status of neurotransmitter and our notions about how synaptic transmission takes place. The involvement of NO and CO in several important aspects of neuronal function suggests that agents affecting the synthesis, transactions, and disposition of these gases are bound to have clinical relevance. [References: 211] DE Animal. Brain/cy [Cytology]. *Brain/ph [Physiology]. *Carbon Monoxide/me [Metabolism]. *Gases/me [Metabolism]. Human. Neurons/ph [Physiology]. Neurotoxins/me [Metabolism]. *Nitric Oxide/me [Metabolism]. *Second Messenger Systems. Support, Non-U.S. Gov't. Support, U.S. Gov't, P.H.S.. RN 0 (Gases). 0 (Neurotoxins). 10102-43-9 (Nitric Oxide). 630-08-0 (Carbon Monoxide). IS 0270-6474 PT Journal Article. Review. Review, Tutorial. LG English NO CIDA NS-01578 (NINDS), MH-18501 (NIMH), DA-00266 (NIDA) EM 9412. Entry Week: 94123. Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=3623