X-Message-Number: 6661 Date: Thu, 1 Aug 1996 03:32:58 -0700 From: Paul Wakfer <> Subject: Prometheus Project Description (updated repost) The Prometheus Project Convincingly demonstrated, scientifically proven and published, fully reversible long-term brain cryopreservation within 10 years As of July 31, 1996, after about six weeks of promotion, first in CryoCare Forum, and then on the Internet through the Cryonet list and the sci.cryonics news-group, pledges of $212,200.00 per year, or a total of $2,122,000.00 payable over a 10 year period have been solicited for the Prometheus Project. These pledges, ranging in yearly value from $1,000 to $25,000, have been made by 38 individuals and 2 organizations. The research project which has been greeted so enthusiastically and supported so strongly is one which several of us have been talking about for many months now since we realized that two of the most critical factors which have kept cryonics small, insecure and unscientific, have become substantially improved. Those two factors are: 1) that current cryobiological methods to reversibly preserve large organs which are now nearing perfection should be applicable to the human brain after suitable modifications, and 2) that the population and the wealth of the cryonics community has reached a size which should enable it to support mainstream cryobiological research to perfect and convincingly demonstrate fully reversible mammalian brain cryopreservation, if cryonicists could only be convinced to do so. Because of its audacity and life-providing purpose we have named this project: The Prometheus Project. If our pledge campaign is successful the project research will be conducted by a for-profit corporation to be formed for this immediate purpose and for the longer-range purpose of producing fully reversible whole-body suspended animation. At this time only solid pledges of $1,000 or more per year for 10 years beginning in 1998 are being requested. When a total of over $1,000,000 per year has been pledged, a company will be formed, an investment prospectus will be issued, share purchase contracts will be signed by all consenting pledgers, the first year's payments will be collected, shares will be issued, and the project will begin. In accordance with SEC regulations, I must state that this writing is not a solicitation for the purpose of purchasing shares in any existing corporation. Needless to say, it is my strong belief, and one I sincerely hope that you will share with me after due consideration of this Project, that the most rewarding aspect of the successful completion of the Prometheus Project will be the almost certain opportunity for each of us to live vastly extended, healthy lives. The Purpose of The Prometheus Project The purpose of the Prometheus Project is to demonstrate by methods which will be convincing to the public and will be published in a peer reviewed scientific journal, the restoration to normal physiological and mental functioning of a mammalian brain which has been preserved and stored at a temperature below -140xC for at least 6 months or which could be so stored for hundreds of years if necessary without additional damage. Logical Necessity of The Prometheus Project for Those Who Wish to Stay Alive The Problem: 1. Unless major scientific anti-aging advances are made, every one of us faces the virtually certain inability of our body to sustain its life within a period of 125 years minus our present age. If you are over 75 years old, the chance of major anti-aging and rejuvenating scientific advances being made soon enough to allow you to live a vastly extended healthy lifetime is virtually zero. If you are over 50 years old, the chance of this is still extremely small. Even if you are only 25 years old, the chance is marginal at best. 2. In order to continue to live, each of us needs a "time machine" to transport him or her, at least mentally intact, into the future. At present there is no method with the proven ability to do this. Even the best current methods of chemical or cryogenic preservation result in massive damage to the body and brain from which any future recovery is at best very uncertain. 3. Furthermore, it has not been proven, and may not even be true that the brain structures which determine our memories, our personality and all of our other precious individual mental attributes are being well preserved through current agonal and cryopreservation processes. 4. The idea of cryonics has been around for 30 years now and the number of people actually signed up has only grown to between 600 and 700. 5. Because of the length of time that it has been around, the publicity which such a radical idea has received, and the plot/entertainment value of such a sensational theme, the cryonics idea is now very widely known. 6. Yet cryonics as currently practiced, remains small and possibly unstable over the long term. Therefore, even if our mental attributes are being preserved through the current agonal and cryopreservation processes, and *can* be fully restored, most people have little confidence that anyone cryopreserved today will reach, still preserved, that possibly far future time when advanced technology *will* be able to effect the necessary restoration. 7. In spite of the multitude of traditional beliefs about death in our society (I'll have had enough; over-crowding of the planet; make a place for the young ones; I'll live on in my children; necessary to insure creativity; it's natural; want to be reincarnated; want to go to heaven; etc. etc. etc.), there are still 100's of thousands if not 10's of millions of people in North America who truly love life and would very much like to have a lot more of it, so long as they could remain mentally and physically healthy. 8. The vast majority of even those who do not accept any of these beliefs about death will never sign-up for, nor support cryonics while they remain relatively healthy, because, being small and unproven it has so little chance of saving them. Instead, they prefer to put any "extra" money into anti-aging methods and research aimed at extending their first "life cycle", giving little thought to the possibility of a *second* "life cycle". The Solution: 1. There does exist a method which has been shown to allow the preservation of a complex organ with no freezing injury at all. With this method viable rabbit kidneys have been recovered from temperatures as low as -40xC, with recovery from much colder temperatures expected soon. This method is called vitrification. It involves turning the organ to be preserved into a glassy substance, cooling it to cryogenic temperatures, and keeping it stored at those temperatures until such time as we wish to recover it for use. Just as glass is fluid at high temperatures and becomes solid as it is cooled to lower temperatures without any crystallization occurring, so too biological tissue, by having its internal water largely replaced with a special solution, can be made to behave like glass and incur no disruptive crystalline formation when it is cooled, even to the temperature of -140xC. (This temperature will be used because it is almost universally agreed by the cryobiological science community that it is sufficiently low to allow storage for several hundred years if necessary with negligible deterioration.) The trick is, however, to use a solution and a method of water removal which does not in itself irreversibly damage the biological tissue. 2. Because this vitrification protocol is organ specific, the exact protocol for kidneys will not work for many other organs. Therefore, if we are ever to achieve suspended animation of the whole human body, we must proceed to make it work for other organs. The most important human organ, and the logical starting point for this purpose is the brain. 3. The scientist who has developed this method of preservation for rabbit kidneys has stated that he does not see any technical reason why this method, with suitable modifications should not be applicable to any mammalian organ including the brain. Furthermore, he has estimated that for any particular organ, the necessary modifications should be able to be discovered and perfected within a time-span of under 10 years and with a project budget of under a million dollars per year. 4. Neuroscience developments and techniques for assessing brain function directly should allow us to convincingly demonstrate the mental attributes of an isolated mammalian brain. It is also believed that it should be possible to do in-situ cryopreservation of a mammalian brain and cooling, perhaps to -70xC, with full recovery of the intact animal. 5. If we can produce a method by which first a mammalian, next a primate, and finally a human brain can be placed in long-term biological stasis and recovered with its functionality including all mental attributes unquestionably alive and complete, we will have the proof that death can be defeated - that in principal, a life can be extended indefinitely. Once convincingly demonstrable, fully reversible, long-term preservation of the brain has been achieved, the mainstream medical and scientific community will accept the scientific validity of the cryonics idea. Major public and private money will be spent to develop methods of providing a body for a restored brain, and to perfect whole-body long- term suspended animation, if possible. The practice of preserving the brain, and later the whole-body, if possible, will become an optional standard medical procedure for the terminally ill and the laws will be changed to accommodate this new paradigm. The Logic of The Prometheus Project Funding Method 1. Those persons who have a great desire for vastly extended life *will* sincerely pledge major amounts of money to a convincingly demonstrable fully reversible brain cryopreservation project if they are convinced that it is necessary in order to achieve such extended life, that it has sound planning which will enable it to succeed if it is funded, and if their pledges are not due until it *does* have sound planning and *is* fully funded. 2. Most of those with incomes over $50K per year (and certainly all of those with incomes over $100K per year) should be able to afford to forgo the present spending of $5-10K per year (at least if tax deductible) without degrading their life-style in any way detrimental to their health and longevity. 3. Within the cryonics and life-extension community, there are well over 200 people who fit this category. Hence, there are a more than sufficient number of people to fund a project which will scientifically demonstrate that long-term reversible brain preservation will work, and therefore, that will be virtually certain to enormously increase the chance of their lives having the potential of immortality. 4. The Prometheus Project defined here is an attainable and fundable goal. The results obtained from the 22 cryonicists on CryoCare Forum (over $100K per year was pledged) strongly suggest that it is realistic to expect to obtain between 100 and 200 pledges of amounts between $5,000 per year and $10,000 per year each for 10 years. Organization of the Collection of the Pledges As founder of the Prometheus Project, Paul Wakfer, one of the $10,000 per year pledgers, will be the person who accepts the pledges and will be the founder and the interim president of the corporation which is formed once the necessary total of $1M per year for 10 years is reached until the Prometheus Project officially begins. If the Prometheus Project pledge campaign succeeds in reaching its target of over $1M per year pledged for 10 years, the pledgers will be able to purchase shares in a for-profit corporation which will be formed to conduct the scientific research of the project. These shares will be purchased over a 10 year period at a fixed price of $100.00 per share with the requirement that an equal amount must be purchased for each of the 10 years. Pledges will not be due and no money will be collected until pledgers who approve the scientific and business plans have signed legally binding share purchase agreements totaling over $1M per year. Any pledger who does not approve of these plans may withdraw his pledge before the Prometheus Project begins. The signing of legally binding share purchase agreements is necessary to insure that the required funding will be forthcoming each year after the project begins. Pledgers who wish to have a tax deduction for the amount of their contribution are encouraged to make arrangements with one of the cryonics organizations or life extension societies which have the ability to issue tax deductible receipts for charitable donations. After the Prometheus Project has begun, those organizations will then use the donated moneys to purchase shares under the same terms as other individual or corporate purchasers. Cryonics organizations which have this capability (or will soon) are: Alcor Life Extension Foundation American Cryonics Society CryoCare Foundation The Immortalist Society All cryonics organizations have been contacted and have been asked for their help in promoting the Prometheus Project through mailings to their membership and advertisements in their periodicals. They have also been asked to accept donation pledges, to turn these into share purchases if the pledge campaign is successful, and, furthermore, to proxy the shareholder voting power of the shares which a donor's money has purchased to that same donor. By this method, individual contributing cryonicists and life extensionists will control the Project instead of the competitive and sometimes antagonistic cryonics organizations. It should be very clear that the success of the Prometheus Project will be extremely beneficial for the cryonics organizations, their members and their patients. In addition, the Life Extension Foundation has agreed to accept donation pledges, and later to accept donations, to issue tax deductible receipts, and to make share purchases under the contractual terms necessary for funding the Prometheus Project. The Prometheus Project will be delighted to accept any pledge of $1000 or more per year, but for administrative and share purchase purposes requires that all pledges be made in units of $100 per year. Again it should be noted that all pledges must be for the same amount per year for all 10 years, although up-front, lump-sum pledges with delivery of shares yearly are also acceptable. A pledge for $8,000 as a lump-sum up-front payment is being accepted as equivalent to a pledge of $1,000 per year for 10 years. Any individual or organization who pledges, and later purchases shares will receive "technology credits" of a dollar value equal to twice that paid for their shares. If the corporation should develop technology which it then sells for the purpose of human cryopreservation, by returning shares to the corporation, these technology credits may be used for purchasing this technology. In this way, if the corporation should develop technology which allows less damaging human cryopreservation, every purchaser of shares who is also a cryonicist or cryonics organization is guaranteed to obtain a return of at least double their investment. If the corporation succeeds in patenting highly marketable discoveries, inventions and procedures, of course, the return from the rise in share price may be far greater. While pledges are being received and are building to the total of $1M per year required, the scientific plan of The Prometheus Project and the business plan of the corporation which will conduct it, will be developed and prepared. Any help that can be contributed to this part of the project (or any other part) is very much welcomed. These plans will be published even in unfinished form as they are developed and prepared. This project is very much a "boot-strap" process. For many reasons, I believe that is the *best* way to accomplish it. I look forward to your questions and suggestions and you can be sure that if the ideas are worthy, they *will* be incorporated into the developing project plans. At this time, the Prometheus Project is essentially a pledge campaign asking a strictly hypothetical question: 1) *If* $1M/yr in pledges for 10 years is collected, and 2) *if* satisfactory scientific and business plans are developed, and 3) *if* the researchers and their projects are satisfactory to you, and 4) *if* a corporation is formed to employ these scientists to execute these projects which issues a prospectus and share offering for that purpose, 4) *then* how much would you be willing to contribute, beginning in 1998, to share purchases of equal amounts for up to 10 years, in that corporation. No money is being requested and no investments are being solicited. If this campaign is not successful no corporation to execute the project will ever be formed. The reason why I believe that the Prometheus Project pledge campaign will be successful is that you are *not* being asked, "how much are you willing to invest in a high-risk, bio-tech R&D startup", even though any corporation which executes the Prometheus Project plan will be all of that. No, you are being asked, "how much of your present life are you willing to commit towards a very good chance at an enormously lengthened future life", and *that* is a significantly different question. Before ending, I wish to leave you with some thoughts. For several weeks now, I have been putting a lot of thought toward what I am now calling the "Prometheus Project" and I very strongly believe that each of us who really wants to live should begin pushing this project constantly and continuously with all the time, money and life-force which he or she can afford without degrading his or her current life below a certain minimum acceptable quality. I have become convinced that if any of us are to survive long-term, one way or the other, this project *must* be accomplished. I believe that the Prometheus Project should be nonpartisan and strongly supported by all organizations because it is much too big for any one cryonics organization. We need all the ideas and help we can get from any source whatever and *I* pledge to promote it and discuss it with absolutely no negativity, innuendo or bias with regard to any particular organization or individual. I expect each organization and each cryonicist to understand why it will be beneficial for them to strongly support the project. We must speak about this project in all our communications and continue to speak of it non- stop, and relentlessly until we have achieved the funding goal. I ask every one of you to include it with every thing you write, hammering away at the idea incessantly, never letting up for a moment until we have done it. The Prometheus Project is not a *charity* for which I am begging you to give up part of your life for some purpose exterior to you which *I* happen to think is important. No! What I am asking is that you honor *yourself*, that exquisite individual consciousness which is yours alone. -- Paul -- !!!!! REVERSIBLE BRAIN CRYOPRESERVATION *CAN* BE ACHIEVED IN 10 YEARS !!!!! Paul Wakfer email: Voice/Fax: Pager: US: 1220 E Washington St #24, Colton, CA 92324 909-481-4433 800-805-2870 Canada: 238 Davenport Rd #240, Toronto, ON M5R 1J6 416-968-6291 416-446-9461 (currently in California) Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=6661