X-Message-Number: 8082
Date: Tue, 15 Apr 1997 21:42:58 -0700 (PDT)
From: Doug Skrecky <>
Subject: CRYONICS 6'th update on fly longevity experiments 

    This is the sixth update on my fly experiments. On day 77 all flies
 from the first run had expired. The two modest winners were forskolin and
 NADH. Since there was no control bottle it is not certain that either of
 these was actually increasing life span.

 First Run             Survival
 Supplement  DAY 21  DAY 31  DAY 43  DAY 56  DAY 67  Day 77

 alpha lipoic  45%     22%     11%      0%      0%      0%
 Biotin        38      12       0       0       0       0
 CLA           43       0       0       0       0       0
 Forskolin     90      80      80      50      10       0
 Glutamine    100      17      17      17       0       0
 Lycopene     100     100      60      20       0       0
 NADH          86      86      86      57      14       0
 Pregnenolone 100      75      37      12       0       0
 Pyroglutaminc 62      50      25      12       0       0
 RNA           57       0       0       0       0       0
 Xanthophyll   62      75      25      12      12       0

    During the day 21 census for the second run I found one extra fly each
 in the acetylcarnitine and clove bottles. Hopefully all the flies in the
 bottles have now been discovered.
    One remarkable finding is that there was no additional mortality in
 the control, nicotinamide, coenzyme Q10, basil, chlorophyll, cloves,
 dextromethorphan, fenugreek, leucoanthocyanin and rosemary bottles. This
 tends to support my hunch that pathogens were causing the early
 mortality. Since the bottles in this run are newer, they are probably
 cleaner than the breeding bottles the flies were derived from. I was
 originally going to start some more breeding bottles and adding thyme to
 help keep the bacteria under control. However since I did not know
 anything about the long term toxicity of thyme I decided to delay
 starting more breeding bottles until a second census had been completed.
 I think the significant decrease in survival in the cumin (100% to 57%),
 oregano (88% to 50%), caraway (67% to 33%) and ginger (67% to 17%)
 bottles may reflect a direct toxic action of these spices. Only the
 coenzyme Q10 and chlorophyll bottles are now maintaining 100% survival.

 Second Run            Survival
 Supplement         DAY 11  DAY 21

 Control              63%     63%
 Nicotinamide         86      86
 Coenzyme Q10        100     100
 Nicotinamide/CoQ10   86      57
 Acetylcarnitine      86      63
 ALC/COQ10           100      86
 Basil                80      80
 Bromelain            78      67
 Caraway              67      33
 Chlorophyll         100     100
 Cloves               83      86
 Cumin               100      57
 Curcumin             71      57
 Dextromethorphan     83      83
 Fenugreek            80      80
 Ginger               67      17
 Green Tea           100      83
 Leucoanthocyanins    86      86
 Mace                 71      57
 Nutmeg               71      57
 Oregano              88      50
 Rosemary             90      90
 Sage                100      75
 Thyme               100      88

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