X-Message-Number: 8293
Date: Sat, 7 Jun 1997 19:41:38 -0700 (PDT)
From: Doug Skrecky <>
Subject: 10'th update on fly longevity experiments
This is the tenth update on my fly experiments. All the flies from the
second run are dead. The results are as follows:
Second Run Survival
Supplement DAY 11 DAY 21 DAY 31 DAY 42 DAY 53 DAY 64
Control 63% 63% 38% 25% 12% 0
Nicotinamide 86 86 86 43 14 0
Coenzyme Q10 100 100 57 0 0 0
Nicotinamide/CoQ10 86 57 29 0 0 0
Acetylcarnitine 86 63 38 12 0 0
ALC/COQ10 100 86 43 14 0 0
Basil 80 80 80 40 0 0
Bromelain 78 67 56 11 0 0
Caraway 67 33 17 17 0 0
Chlorophyll 100 100 67 14 14 0
Cloves 83 86 57 0 0 0
Cumin 100 57 71 43 0 0
Curcumin 71 57 29 14 0 0
Dextromethorphan 83 83 67 33 0 0
Fenugreek 80 80 40 20 0 0
Ginger 67 17 0 0 0 0
Green Tea 100 83 67 33 0 0
Leucoanthocyanins 86 86 57 14 0 0
Mace 71 57 29 0 0 0
Nutmeg 71 57 57 29 0 0
Oregano 88 50 25 0 0 0
Rosemary 90 90 64 10 0 0
Sage 100 75 75 62 25 0
Thyme 100 88 25 12 0 0
Overall I wasn't too impressed by any of the supplements tested during
the second run. Although sage, followed by nicotinamide and chlorophyll
look a little interesting, the increased survivals may merely be an
artifact of a decrease in early mortality and may not be due to any
antiaging effect. I'm taking a look at higher dosages of sage and
nicotinamde in the third run. The preliminary results for this are as
follows:
Third Run Day 17 Census
Supplement #Alive #Dead %Survival
Control 9 5 64%
Activated charcoal 20 3 87
Amchoor 8 3 73
Angelica 19 15 56
Anise 5 6 45
Bay 9 4 69
Beet 5 3 62
Betaine HCL 9 2 82
Carrot 4 6 40
Celery seed 9 1 90
Citrus bioflavonoids 13 7 65
Comfrey 7 1 88
Dill seed 9 2 82
Green pea 25 8 76
Hydroxycitric acid 7 8 47
Kelp 9 5 64
Malt 30 6 83
Melatonin 7 6 54
Melatonin 2X 12 5 70
Melatonin 4X 13 7 65
Nicotinamide 6X 4 10 28
Paprika 9 4 69
Para-aminobenzoic acid 14 3 82
Purple yam 11 1 92
Rosehip 15 2 88
Sage 19 10 66
Sage 2X 12 6 67
Sage 4X 15 1 94
Silica 14 2 88
Spinach 2 3 40
Tumerin 16 3 84
Although the breeding bottles used for the third run contained some
thyme to help act as a bactericide, this apparently was not enough to
prevent a lot of early mortality in the third run. I will have to use a
better bactericide for the breeding bottles I will use for the fourth
run.
It is too early to tell if any supplement is exerting any antiaging
effect. However it does appear that a dosage of nicotinamide six times as
high as that used in the second run is toxic. At just 28% the nicotinamde
bottle has the lowest survival. This reminds me of the results obtained
long ago with vitamin B5, where a low dosage increased survival and a
high dosage decreased it. I wonder whether excessive dosing with vitamins
was a factor in making Durk Pearson look older than he is. It is possible
that this famous life extensionist has indeed succeeded in altering his
rate of aging, just that it is unfortunately an increase rather than a
decrease in the rate.
This run I used more flies for most bottles than in previous runs.
However whenever the number of flies in a bottle rose above 20, I found I
nearly had to go cross-eyed to count all these flies as they moved
around. In future I will keep the numbers always below 20. ;)
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