X-Message-Number: 9248 Date: Fri, 6 Mar 1998 08:42:04 -0800 (PST) From: Doug Skrecky <> Subject: Treatment With L-Deprenyl Prolongs Life in Elderly Dogs Life Sciences 61(11): 1037-1044 1997 Summary: Eighty two beagle dogs ranging in age from 2.8 to 16.4 years and in weight from 6.3 to 15.8 kg were allotted to 41 pairs and administered placebo or 1 mg/kg l-deprenyl orally once daily for 2 years and 10 weeks. When survivorship for all dogs in the study was analyzed there was no significant difference between the l-deprenyl and placebo treated groups, most likely due to the (expected) survival of virtually all young dogs in both groups for the duration of the study. To assess whether l-deprenyl treatment begun in later life might enhance canine longevity in a fashion similar to that documented in rodents we also examined survival in a fashion similar to that documented in rodents we also examined survival in a subset of elderly dogs who were between the ages of 10 and 15 yrs at the start of tablet administration and who recieved tablets for at least 6 months. In this subset, dogs in the l-deprenyl group survived longer (p<0.05) than dogs in the placebo group. Twelve of 15 (80%) dogs in the l-deprenyl group survived to the conclusion of the study, in contrast to only 7 of 18 (39%) of the dogs who recieved placebo (p=0.017). Furthermore, by the time the first l-deprenyl treated dog died on day 427, 5 placebo treated dogs had already succumbed, the first on day 295. Specifically with respect to dogs, the findings reported herein suggest daily oral administration of 1 mg/kg l-deprenyl prolongs life when begun in relatively healthy dogs 10-15 years of age and maintained for the duration of the individual's life, but in any event for no less than six months. Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=9248