X-Message-Number: 9528
Date: Mon, 20 Apr 1998 13:36:41 -0700 (PDT)
From: Doug Skrecky <>
Subject: DMSO penetration into organs

Authors
  Isbell SA.  Fyfe CA.  Ammons RL.  Pearson B.
Institution
  Perceptual and Motor Skills, Missoula, Montana 59807, USA.
Title
  Measurement of cryoprotective solvent penetration into intact organ tissues
  using high-field NMR microimaging.
Source
  Cryobiology.  35(2):165-72, 1997 Sep.
Abstract
  Existing methods are not able to monitor accurately the penetration of
  cryoprotective solvents (CPS) into intact tissues. In this study, NMR imaging
  is shown to be a noninvasive nondestructive way to measure penetration rates
  and effective diffusion coefficients of Me2SO into samples of rat kidney and
  rat liver tissues. This new method is unique in that the measurements
  obtained are not averaged over the entire tissue volume but may be made at
  any site in the tissue. Measurements of penetration rates yield values which
  are similar to literature values, and the effective diffusion coefficients
  fall within the expected range. The images also suggest an explanation of why
  CPSs fail to completely protect organs from freezing damage. Copyright 1997
  Academic Press.

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