X-Message-Number: 9636
Date: Wed, 6 May 1998 08:45:42 -0700 (PDT)
From: Doug Skrecky <>
Subject: stabilization of dry liposomes

Authors
  Crowe LM.  Crowe JH.
Institution
  University of California, Davis 95616.
Title
  Stabilization of dry liposomes by carbohydrates.
Source
  Developments in Biological Standardization.  74:285-94, 1992.
Abstract
  Many organisms have adopted biochemical strategies that enable them to
  survive dehydration, a condition known as "anhydrobiosis".
  In addition to resistance to the deleterious effects of drying, anhydrobiotes
  are also resistant to a number of other adverse environmental conditions.
  Studies on the biochemistry of anhydrobiotes show a strong correlation
  between their ability to survive drying and the production of specific
  sugars, of which the most widely studied is trehalose. Studies of model
  systems show that direct interactions of trehalose with dry biological
  membranes, liposomes, and isolated proteins avoid the damaging events caused
  by drying. Cellular components are maintained in a physical state when dry
  that mimics the hydrated state. Although the presence of only two
  disaccharides, trehalose and sucrose, has been correlated with survival of
  drying under natural conditions, other molecules that achieve the same
  results may be effective.

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