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Msg | Description |
# 13376 | drosophila longevity experiments [Doug Skrecky] |
Skrecky <oberon@vcn.bc.ca>
Subject: drosophila longevity experiments
Citations: 1-4
<1>
Authors
Mockett RJ. . . . air. Under hyperoxic conditions, overexpressors had increased
longevity, decreased accrual of protein carbonyls, and
dramatically . . . of glutathione
reductase had no effect on longevity, protein carbonyl
content, reduced glutathione, or glutathione . . . in protein levels. The NAC effect on
longevity may involve differential expression of specific
mRNA genes, as suggested by RNA finger-printing experiments.
<3>
Authors
Anisimov VN. Mylnikov SV. Oparina . . . ketodienes (KD) and
conjugated hydroperoxides (CHP) in fly tissues at the age of 11 days.
(Thu, 9 Mar 2000, 8 KB) |
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# 25555 | trace episodic hydrogen peroxide as a life extender? [Doug Skrecky] |
20 mM H2O2 increased human skin cell longevity in vitro by 60%.
(ref #1) This . . . up on with an
in vivo rodent longevity experiment. There was one study on house flies
. . . it by 27%. Although 10
mM increased fly's glutathione by 98%, 5 mM actually (Sat, 15 Jan 2005, 6 KB) |
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# 25707 | Vitamin K not for Canadians [Doug Skrecky] |
will
> prolong lifespan, then do the necessary experiments to show or
> not that it will. . . . vitamin K2, so I can do a fly longevity test on this supplement, please
contact me (Mon, 21 Feb 2005, 1 KB) |
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# 19832 | Re: CR going mainstream [Scott Badger] |
lived men revealed
three correlates to their longevity; lower than
average levels of glucose, lower . . . insulin.
I wonder if Doug has done fly experiments using
glucose rich food vs low glucose (Sun, 18 Aug 2002, 4 KB) |
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# 13260 | ON THE POSSIBILITIES FOR POSTPONEMENT OF HUMAN AGING [Eugene Leitl] |
alive.
4) Evolutionary theory and some crude experiments suggest
that hundreds of genetically determined biochemical pathways
influence longevity and might thus be manipulated to postpone
. . . nematode) Caenorhabditis elegans and in the fruit fly
Drosophila melanogaster. Whether results in these organisms (Tue, 15 Feb 2000, 19 KB) |
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# 28533 | mild protein restriction increases drosophila lifespan [Doug Skrecky] |
restriction in drosophila, with the best controlled experiments finding a
null result on longevity. Tatar offers the best explanation to date . . . research reports of a number of these experiments, and
found some evidence that although calorie decreases did not offer a
consistent longevity benefit, the evidence did point to reduced . . . a threshold effect, where
excess calories reduce longevity only above a (high) threshold.
Calorie intake is believed to modulate mammal longevity partly by
body temperature reduction to help . . . may have found the
protein content of fly food that maximizes macroautophagy in drosophila.]
Mech (Thu, 28 Sep 2006, 3 KB) |
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# 15161 | "Who wants to live forever?" [Mark Plus] |
pointed out one reason for such unusual longevity in The
Republic . An old man is . . . so widely and profitably peddled. The only
experiments on laboratory animals that have definitely shown . . . They are so
long-lived that any experiment would have to continue for many years . . . different approach might work. To some extent longevity is an inherited
trait. Experiments with that old friend of science, the fruit fly, have
shown that selective breeding for long (Fri, 22 Dec 2000, 12 KB) |
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# 23963 | How long do you think we've got till. . . [michaelprice] |
promising.
Have a look at http://mcp.longevity-report.com for a more detailed analysis
. . . Drosophila Melanogaster as a Screening Agent for Longevity
Factors. I. Pantothenic Acid as a Longevity Factor in Royal Jelly. Thomas
S Gardner, . . . Drosophila Melanogaster as a Screening Agent for Longevity
Factors. II. The Effects of Biotin, Pyridoxine, . . . on the Life Span of the Fruit Fly. Thomas S Gardner,
Journal of Gerontology 1( . . . of Various Origin upon the Growth and
Longevity of the white mouse. TB Robertson in . . . about the
Evans-Meyer-Pouchnik chromium picolinate experiment on rats: Cohort maximum
lifespan (last survivor) (Fri, 23 Apr 2004, 7 KB) |
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# 8286 | Life Extension Supplements: Screens on Lower Organisms [Brian Rowley] |
Skrecky dug up all
Medline-accessible fruit fly mortality studies where anti-aging drugs were
. . . exists is almost entirely from one-dose
experiments. For example, melatonin mortality studies I've . . . is to slow mammalian aging, not fruit fly aging. Fruit
flies don't die of . . . fruit flies, humans and paramecia share basic longevity
assurance mechanisms: all have antioxidant defense enzymes, (Thu, 5 Jun 1997, 9 KB) |
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# 15160 | "Gerontological Incertitude" [Mark Plus] |
is rather like one
of the Mars fly-by probes, but engineered to reproduce, not . . . suggest that roughly 35% of man s longevity is due to genetic factors, the
rest . . . will lengthen the animals lifespan.
Hope and experience
There is great hope amongst biologists that (Fri, 22 Dec 2000, 10 KB) |
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